55 publications

Citations: >1300

H-index (at age 39) 24 (Google Scholar).

Accepted Manuscripts: 

(55) Ross W Paterson; Alexander J. Ehrenberg; Ayesha Khatun; Emma Coomans; Matthew J. Betts; Federica Capraro; Elisabeth H. Thijssen; Konstantin Senkevich; Tehmina Bharucha; Merhsa Jafarpour; Peter NE Young; William Jagust; Stephen F. Carter; Tammaryn Lashley; Lea T. Grinberg; Joana B. Pereira; Niklas Mattsson; Nicholas J. Ashton; Jörg Hanrieder; Henrik Zetterberg; Michael Schöll. "Relevance of biomarkers in different neurodegenerative diseases." Alzheimers Res Ther 2020 (accepted) (Review)


(54) Obrocki P, Khatun A, Ness D, Senkevich K, Hanrieder J, Capraro F, Mattsson N, Andreasson U, Portelius E, Ashton NJ, Blennow K, Schöll M, Paterson RW, Schott JM, Zetterberg H.

"Perspectives in fluid biomarkers in neurodegeneration from the 2019 biomarkers in neurodegenerative diseases course-a joint PhD student course at University College London and University of Gothenburg" 

Alzheimers Res Ther. 2020 12(1):20. doi: 10.1186/s13195-020-00586-6. (Review)


(53) Michno W, Wehrli P, Sehlin D, Syvänen S, Zetterberg H, Blennow K, Hanrieder J.*
“Chemical imaging of evolving amyloid plaque pathology and associated Aβ peptide aggregation in transgenic AD Mice J.Neurochem  2020 152(5):602-616.


(52) Wehrli P, Michno W, Zetterberg H, Blennow K, Hanrieder J.*

“Chemometric Strategies for Sensitive Annotation and Validation of Anatomical Regions of Interest in Complex Imaging Mass Spectrometry Data” J Am Soc Mass Spectrom 2019 30(11):2278-2288


(51) Jonsson M., Nyström S., Sandberg A., Carlback M., Starkenberg A.,

 Michno W., Hanrieder J., Nilsson K.P.R., Thor S., Hammarström P.

“Amyloid fibril polymorphism and cell specific toxicity in vivo” Amyloid 2019 26(sup1):136-13


(50) Michno W, Nyström S, Lashley T., Wehrli P., Brinkmalm G., Kaya I, Brinet, D., Guerard L, Syvänen S., Sehlin D., Nilsson KPR, Hammarström P, Blennow K, Zetterberg H, Hanrieder J.*

“Pyroglutamation of Aβx-42 followed by Aβ1-40 deposition underlie priming and maturation of diffuse into cored plaque morphotypes in progressing Alzheimer’s disease pathology”

2019 J Biol Chem 294(17):6719-6732


(49) Michno W., Wehrli P., Zetterberg H., Blennow, K., Hanrieder J.*

“GM1 locates to mature amyloid structures implicating a prominent role for glycolipid-protein interactions in Alzheimer pathology” 2018 Biochim. Biophys. Acta 2019 (1867(5):458-467 (Invited Contribution, Cover)

(48) Kushnir MM., Michno W., Rockwood AL., Blennow K., Strathman JG, Hanrieder J. “Association of PTHrP Levels in CSF with

Alzheimer's Disease Biomarkers”

Clinical Mass Spectrometry 2018 9.Oct (in print)


(47) Michno W, Kaya I, Nyström S, Guerard L, Nilsson KPR,

Hammarström P, Blennow K, Zetterberg H, Hanrieder J.*

“Multimodal Chemical Imaging of Amyloid Plaque Polymorphism Reveals

Aβ Aggregation Dependent Anionic Lipid Accumulations and Metabolism” 2018

Anal Chem. 90(13):8130-8138


(46) Michno W., Wehrli P. Blennow, K., Zetterberg H., Hanrieder J.*

“Molecular Imaging Mass Spectrometry for Probing Protein Dynamics in Neurodegenerative Disease Pathology.” 2018 J. Neurochem. (in print) (Invited Review by the Editor based on my experience in the field, Cover)

(45) Jonsson M., Nyström S., Sandberg A., Carlback M., Starkenberg A.,

 Michno W., Hanrieder J., Nilsson K.P.R., Thor S., Hammarström P.

“Aggregated Aβ1-42 is selectively toxic for neurons, whereas glial

 cells produce mature fibrils with low toxicity in Drosophila”

Cell Chemical Biology 2018 25(5):595-610.e5


(44) Kaya I., Zetterberg H., Blennow K., Hanrieder J.*

”Shedding Light on the Molecular Pathology of Amyloid Plaques in Transgenic Alzheimer’s Disease Mice using Multimodal MALDI Imaging Mass Spectrometry”

ACS Chem Neurosci 2018 9(7):1802-1817


(43) Kaya I., Brinet D., Michno W., Baskurt M., Zetterberg H, Blennow K., Hanrieder J.*

“Novel Trimodal Imaging Mass Spectrometry (IMS3) At 10 mm Reveals Spatial Lipid and Peptide Correlates Implicated in Alzheimer’s Disease Related Ab Plaque Pathology”

ACS Chem Neurosci. 2017 8(12):2778-2790


(42) Kaya I., Michno W., Brinet D., Iacone Y., Blennow K., Zetterberg H., Hanrieder J.*

“Histology Compatible MALDI based Imaging of Neuronal Lipids for Subsequent Immunofluorescence Staining” Anal. Chem. 2017. 89(8):4685-4694


(41) Kaya I., Brinet D., Michno W., Sehlin D., Syvänen S., Zetterberg H, Blennow K., Hanrieder J.* “Delineating Amyloid Palque Pathology Associated Sphingolipid Regulations in Alzheimer’s Disease” ACS Chem Neurosci. 2017 8(2):347-355


(40) Karlsson, O., Michno W., Ransome, Y., Hanrieder, J.* “MALDI imaging delineates hippocampal glycosphingolipid changes associated with neurotoxin induced proteopathy following neonatal BMAA exposure” Biochim. Biophys Acta 2016 pii: S1570-9639(16):30261-8

(Invited by the Editor for a Special Issue)


(39) Karlsson, O., Hanrieder, J. “Imaging mass spectrometry in drug development and toxicology” Arch Toxicol.2016 91(6):2283-2294 (Review)


(38) Zanni G., Michno W., Di Martino E., Tjärnlund-Wolf A., Pettersson J., Mason C.E., Hellspong G., Blomgren K., Hanrieder J*. “Lithium Accumulates in Neurogenic Brain Regions as Revealed by High Resolution Ion Imaging”

Sci. Rep. 2017 7:40726

(37) Carlred L., Michno W., Sjövall PS., Syvänen S., Hanrieder J.*,  

“Probing Plaque Pathology in tgArcSwe mice of Alzheimers Disease

Using MALDI Imaging”

J Neurochem 2016 183 (3):469-478 (Cover)


(36) Sjövall PS., Rossmeisl M., Hanrieder J., Kuda O. ,Kopecky J., Bryhn M.,

“Dietary uptake of omega-3 fatty acids in mouse tissue studied by time-of-flight

secondary ion mass spectrometry” Anal.Bioanal.Chem. 2015 407(17):5101-11


(35) Hanrieder J., Malmberg P., Ewing AG. “Spatial Neuroproteomics using

Imaging Mass Spectrometry” Biochim. Biophys Acta 2015 54(7):718-31 (Review)


(34) Karlsson O., Berg AL., Hanrieder J., Arnerup G., Lindström AB, Brittebo EB.

"Intracellular fibril formation, calcification and enrichment filament proteins in the

adult hippocampus CA1 following neonatal exposure to BMAA"

Arch Toxicol. 2015 89(3):423-36.


(33) Hanrieder J., Ewing AG. “Spatial Spinal Cord Lipid and Metabolite Regulations in Amyotrophic Lateral Sclerosis revealed by ToF SIMS imaging”

Sci. Rep. 2014 4:5266


(32) Hanrieder J.*, Gerber L., Persson Å., Brittebo EB., Ewing AG., Karlsson O.

"High Resolution Metabolite Imaging in the Hippocampus Following Neonatal

Exposure to the Environmental Toxin BMAA using ToF-SIMS"

ACS Chem Neurosci. 2014 5(7):568-75 (Cover)


(31) Gerber L., Hoang VM., Malmberg P., Hanrieder J., Ewing AG

“Using imaging ToF-SIMS data to determine the cell wall thickness

of fibers in wood”

Surf. Interf. Anal. 2014 46 (46 (2014) 225-228 DOI: 10.1002/sia.5661


(30) Bergquist M., Jonasson S., Hjoberg J., Hedenstierna G., Hanrieder J.*

” Comprehensive multiplexed protein quantitation delineates moderate and severe experimental asthma” BMC Pulm. Med. 2014 14(1):110


(29) Hanrieder J.*, Karlsson O., Brittebo EB., Malmberg P., Ewing AG.

“Probing the lipid chemistry of neurotoxin induced hippocampal lesions using multimodal imaging mass spectrometry” Surf. Interf. Anal. 2014 46(Suppl 1):375-378


(28) Hanrieder J., Malmberg P., Lindberg OR., Fletcher JS., Ewing AG.

“Time-of-Flight Secondary Ion Mass Spectrometry Based Molecular Histology of Human Spinal Cord Tissue and Motor Neurons” Anal. Chem. 2013 85(18) 8741-48


(27) Phan NTN., Hanrieder J., Berglund EC., Ewing AG.

“Capillary Electrophoresis–Mass Spectrometry-Based Detection of Drugs and Neurotransmitters in Drosophila Brain” Anal. Chem. 2013 85(17) 8448-54


(26) Berglund C., Kuklinski N., Karagündüz E., Ucar K., Hanrieder J., Ewing AG.

“Freeze-Drying as Sample Preparation for MECK- Electrochemical Separations

of Neurochemicals in Drosophila Brains” Anal. Chem 2013 85(5) 2841-2846

(25) Hanrieder J., Phan TN., Kurczy M., Ewing AG.   “Imaging Mass Spectrometry

in Neuroscience” ACS Chem. Neurosci. 2013 4(5) 666-79 (Cover)


(24) Ljungdahl A, Hanrieder J., Bergquist J., Andersson M.

“Analysis of neuropeptides by MALDI imaging MS”

In: The low molecular weight proteome. Methods Mol Biol 2013 1023,

121-36 (Book Chapter)


(23) Hanrieder J.*, Ekegren T., Andersson M., Bergquist J.

”MALDI Imaging of Post Mortem Human Spinal Cord in Amyotrophic Lateral Sclerosis”

J. Neurochem. 2013 124(5) 695-707


(22) Hambiliki F.#, Hanrieder J.#, Bergquist J., Hreinsson J.,Stavreus-Evers A.,

Wånggren K. “Glycoprotein 130 promotes human blastocyst development in vitro”

Fert.Stert. 2013 99(6) 1592-99


(21) Botling-Taube A.,  Hardenborg E., Wetterhall M., Hanrieder J., Andersson M., Bergquist J., “Protein content in aqueous humor from patients with pseudoexfoliation (PEX) investigated by” Eur.J.Mass Spetrom. 2013 18 (6) 531-541


(20) Hanrieder J., Ljungdahl A., Andersson M. "MALDI Imaging Mass Spectrometry of Neuropeptides in Parkinson’s Disease" J. Vis. Exp. 2012 14(60),pII:3445 (Review)


(19) Karlsson O., Berg AL., Lindström AK., Hanrieder J., Arnerup G., Roman E., Brittebo E., Andersson M. ”Neonatal exposure to the cyanobacterial toxin BMAA induces changes in protein expression, and neurodegeneration in adult hippocampus” Toxicol. Sci. 2012 130(2) 391-404


(18) Füvesi J, Hanrieder J., Bencsik K, Rajda C, Kovács SK, Kaizer L, Beniczky S, Vécsei L, Bergquist J. “Proteomic analysis of cerebrospinal fluid in a fulminant case of multiple sclerosis” Int. J. Mol. Sci. 201213(6):7676-93


(17) Brishammar S., Hanrieder J., Bergquist J.

“TMV-particle borne enhancer of a tobacco RNA-replicase” WJST 2012 2(7)


(16) Hanrieder J.#, Ljungdahl A.#, Eriksson Mammo S., Fälth M., Bergquist J., Andersson M., "L-DOPA induce Dyskinesia is Associated with Regional Increase of Striatal Dynorphin Peptides as Elucidated by Imaging Mass Spectrometry"

Mol. Cell. Proteomics 2011 10(10):M111.009308


(15) Ljungdahl A., Hanrieder J., Fälth M., Bergquist J., Andersson M “Imaging Mass Spectrometry Reveals Elevated Nigral Levels of Dynorphin Neuropeptides in L-DOPA-induced Dyskinesia in Rat Model of Parkinson’s Disease”

PLoS One 2011;6(9):e25653.


(14) Hanrieder J.*, Wicher G, Bergquist J, Andersson M, Fex-Svenningsen Å. “MALDI mass spectrometry based molecular profiling of neural cells for prediction in mammalian brain”

Anal. Bionanal. Chem. 2011 401(1) 135-147


(13) Wetterhall M., Zuberovic A., Hanrieder J., Bergquist J. “Shotgun proteomic evaluation of spin colums for removal of high abundant protein in human CSF”

J. Chromatogr. B 2010 878(19) 1519-1530


(12) Zuberovic A., Wetterhall M., Hanrieder J., Bergquist J.

“CE MALDI-TOF/TOF MS for multiplexed quantification of proteins in human ventricular CSF” Electrophoresis2009 30(10) 1836-43


(11) Hanrieder J.#, Zuberovic A.#, Bergquist J. „Multidimensional solution phase electrophoresis coupled to MALDI MS for proteomics of human follicular fluid”

J.Chromatogr. A 2009 1216(17) 3621-28


(10) Hanrieder J., Wetterhall M., Hillered L., Enblad P., Bergquist J. “Differential Proteomic Analysis of Human Ventricular CSF for Monitoring TBI Biomarkers“

J.Neurosci.Meth. 2009 177(2) 469-478


(9) Ramström M., Zuberovic A., Grönwall C., Hanrieder J., Bergquist J., Hober S., “Affinity Columns for the Removal of High-Abundant Proteins in Cerebrospinal Fluid" Biotechnol.Appl.Biochem. 2009 52, 159-166


(8) Hardenborg E., Botling-Taube A., Hanrieder J., Andersson M., Bergquist J., “Protein content in aqueous humor from patients with pseudoexfoliation (PEX) investigated by capillary-LC MALDI-TOF/TOF MS” Proteomics Clin.Appl. 2009 3(3) 299–306


(7) Nilsson E., Hanrieder J., Bergquist J., Larsson A. “Proteomic Characterization

of IgY preparations” J.Agric.Food.Chem. 2008 56(24) 11638-42.


(6) Ekegren T.#, Hanrieder J.#, Bergquist J.,“Clinical Perspectives of

High Resolution Mass Spectrometry based Proteomics in Neuroscience”

J. Mass Spectrom. 2008 43(5) 559-571 (Review, Cover)


(5) Zuberovic A., Hanrieder J., Bergquist J., Wetterhall M.

“Exploring the potential of CE with surface modified capillaries for analysis of

complex biological samples”

Eur. J. Mass. Spectrom. 2008 14(4) 249-260


(4) Hanrieder J., Nyakas A., Naessen T., Bergquist J. “Proteomic Analysis of

Human Follicular Fluid Using an Alternative Bottom-Up Approach”

J. Proteome Res. 2008 7(1) 443-449


(3) Fedulova N., Hanrieder J., Bergquist J., Emren LO. “Expression and purification of catalytically active human PHD3 in E.coli” Prot.Expr. Purif. 2007 54(1) 1-10


(2) Ekegren T., Hanrieder J., Aquilonius SM., Bergquist J., “Focused Proteomics in Post-Mortem Human Spinal Cord” J. Proteome Res. 2006 5(9) 2364-71


(1) Otvos LJr., Wade D., Feng J. Q., Hanrieder J., Hoffmann, R., “Designer combinatorial antibacterial peptides kill fluoroquinolone-resistant clinical isolates” J. Med. Chem. 2005 48(16) 5349-59


Book Chapters:


Hanrieder J.*, Zetterberg H, Blennow K

“MALDI Imaging Mass Spectrometry: Neurochemical Imaging of Proteins and Peptides“ in Neuroproteomics 2ndEdition,  Springer Protocols, Neuromethods 146, Ka Wan Li (Ed.) Humana Press 2019


*corresponding author, #equal contribution